28.07.2021

Quintupling Inhaled Glucocorticoids to Prevent Childhood Asthma Exacerbations

Supported by the National Heart, Lung, and Blood Institute.

Disclosure forms provided by the authors are available with the full text of this article at NEJM.org.

Dr. Jackson reports receiving fees for serving on an advisory board from Vectura Group, Boehringer Ingelheim, and GlaxoSmithKline and consulting fees from Novartis; Dr. Bacharier, receiving consulting fees and lecture fees from Aerocrine, GlaxoSmithKline, Genentech–Novartis, Teva Pharmaceuticals, and Boehringer Ingelheim, fees for serving on an advisory board and lecture fees from Merck, consulting fees from Cephalon, fees for serving on a data and safety monitoring board from DBV Technologies, lecture fees from AstraZeneca, honoraria for continuing medical education (CME) program development from WebMD–Medscape, and fees for serving on an advisory board from Sanofi, Vectura Group, and Circassia; Dr. Mauger, receiving drugs for trials from Merck and Boehringer Ingelheim; Dr. Chmiel, receiving honoraria from Nivalis Therapeutics, honoraria paid to his institution from Corbus Pharmaceuticals, and consulting fees from Verona Pharma, Catabasis, Albumedix, and Patara Pharma; Dr. Morgan, receiving fees for serving as co-chair of an epidemiologic study of cystic fibrosis for Genentech; Dr. Peters, receiving fees for serving on an advisory board from AstraZeneca, Boehringer Ingelheim, Sunovion Pharmaceuticals, Teva Pharmaceuticals, and Regeneron Pharmaceuticals–Sanofi, fees for serving on a data and safety monitoring board from Gilead Sciences, Genentech, and Novartis, fees for clinical-trial adjudication from Quintiles, fees for CME WebEx from PRIME, and fees for a CME program from Haymarket Media Group; Dr. Cabana, receiving fees for serving on a speakers bureau from Merck and consulting fees from Thermo Fisher Scientific, Genentech, and Novartis; Dr. Martinez, receiving grant support from Johnson Johnson and consulting fees from Compañía Agropecuaria Copeval and Commense; Dr. Pongracic, receiving study drugs from Boehringer Ingelheim, GlaxoSmithKline, Teva Pharmaceuticals, and Merck; Dr. Covar, receiving grant support from Roche and AstraZeneca; Dr. Gentile, receiving grant support and lecture fees from Stallergenes Greer; Dr. Israel, receiving consulting fees from AstraZeneca, Philips Respironics, Regeneron Pharmaceuticals, Bird Rock Bio, Nuvelution Pharmaceuticals, Vitaeris, and Entrinsic Health Solutions, receiving consulting fees and fees for serving on data and safety monitoring board from Novartis, serving as unpaid member of a data and safety monitoring board for a trial funded by Novartis, receiving travel support from Research in Real Life, receiving consulting fees, travel support, and study drugs from Teva Specialty Pharmaceuticals, receiving grant support from Genentech, receiving grant support and study drugs from Boehringer Ingelheim, receiving consulting fees and study drugs from GlaxoSmithKline and Merck, receiving study drugs from Sunovion, and receiving grant support and consulting fees from Sanofi; Dr. Ly, receiving lecture fees from ABcomm and fees for serving on an advisory board from Gilead Sciences; and Dr. Ross, receiving study drugs from Boehringer Ingelheim, GlaxoSmithKline, and Merck and grant support and study drugs from Teva Pharmaceuticals. No other potential conflict of interest relevant to this article was reported.

This article was published on March 3, 2018, at NEJM.org.

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