Supported by a grant (FP7/2007-2013) from the European Union 7th Framework Program and by the German Heart Research Foundation and the German Cardiac Society.
Disclosure forms provided by the authors are available with the full text of this article at NEJM.org.
Dr. Landmesser reports receiving lecture fees and advisory-board fees from Abbott and Biotronik and grant support from the German Center for Cardiovascular Research; Dr. Piek, receiving travel support from Abbott Vascular and advisory-board fees and travel support from Philips Volcano; Dr. Noc, receiving consulting fees from ZOLL Circulation, lecture fees from Maquet Getinge, and grant support from AstraZeneca; Dr. Goslar, receiving lecture fees from AstraZeneca; Dr. Montalescot, receiving grant support paid to his institution, consulting fees, advisory-board fees, and lecture fees from Amgen, AstraZeneca, Bayer, Boehringer Ingelheim, Bristol-Myers Squibb, Daiichi Sankyo, Eli Lilly, Medtronic, Merck Sharpe and Dohme, Pfizer, and Sanofi, grant support paid to his institution from Celladon, consulting fees from Beth Israel Deaconess Medical Center, Brigham and Women’s Hospital, Menarini, the TIMI Study Group, and Actelion, lecture fees and education fees from the Cardiovascular Research Foundation, DME Resources, Europa, Lead-Up, WebMD, and Agence CCC, and review fees and education fees from Elsevier; Dr. Windecker, receiving grant support from Biotronik, Boston Scientific, Bracco, Edwards Lifesciences, Medtronic, Terumo, and St. Jude Medical; Dr. Savonitto, receiving grant support from Novartis, Daiichi Sankyo, and Eli Lilly and lecture fees from Pfizer, Bristol-Myers Squibb, AstraZeneca, and Bayer; and Dr. Zeymer, receiving lecture fees from AstraZeneca, Bayer, Boehringer Ingelheim, Bristol-Myers Squibb, Novartis, Sanofi, MSD, The Medicines Company, Pfizer, Daiichi Sankyo, Eli Lilly, and Abiomed. No other potential conflict of interest relevant to this article was reported.
Drs. Desch and Zeymer contributed equally to this article.
This article was published on October 30, 2017, at NEJM.org.
We thank the patients who agreed to participate in this trial and their relatives, the trial contributors, and the investigators who recruited the patients.