05.12.2021

Fremanezumab for the Preventive Treatment of Chronic Migraine

Supported by Teva Pharmaceuticals.

Disclosure forms provided by the authors are available with the full text of this article at NEJM.org.

Dr. Silberstein reports receiving consulting fees from Alder BioPharmaceuticals, Allergan, Amgen, Automatic Technologies, Avanir Pharmaceuticals, Curelator, Depomed, Dr. Reddy’s Laboratories, electroCore, Eli Lilly, eNeura, Insys Therapeutics, Supernus Pharmaceuticals, Teva Pharmaceuticals, Theranica Bio-Electronics, and Trigemina; Dr. Dodick, receiving consulting fees from Acorda Therapeutics, Alder BioPharmaceuticals, Allergan, Amgen, Automatic Technologies, Biocentric, Biohaven, Boston Scientific, Charleston Laboratories, CoLucid Pharmaceuticals, Dr. Reddy’s Laboratories, Eli Lilly, eNeura, Insys Therapeutics, Ladenburg Thalmann, Magellan, Merck, Neuro Assessment Systems, Pfizer, Promius Pharma, Teva Pharmaceuticals, Tonix Pharmaceuticals, Trigemina, Xenon Pharmaceuticals, and Zosano Pharma, owning stock options in Epien Medical, Mobile Health, and Nocira, and serving on the board of King-Devick Test; Dr. Bigal, being an employee of Teva Pharmaceuticals; Dr. Yeung, being an employee of Teva Pharmaceuticals; Dr. Goadsby, receiving consulting fees from Akita Biomedical, Alder BioPharmaceuticals, Avanir Pharmaceuticals, Cipla, Dr. Reddy’s Laboratories, electroCore, Novartis, Pfizer, Quest Diagnostics, Scion Pharmaceuticals, and Teva Pharmaceuticals, receiving consulting fees and grant support from Allergan, Amgen, Eli Lilly, and eNeura, receiving consulting fees from and holding stock options in Trigemina, and holding a patent, licensed to eNeura, for “Methods and systems for preventative migraine headache treatment” (WO2016090333 A1); Ms. Blankenbiller, being an employee of Teva Pharmaceuticals; Ms. Grozinski-Wolff, being an employee of Teva Pharmaceuticals; Dr. Yang, being an employee of Teva Pharmaceuticals; Ms. Ma, being an employee of Teva Pharmaceuticals; and Dr. Aycardi, being an employee of Teva Pharmaceuticals. No other potential conflict of interest relevant to this article was reported.

We thank the patients who participated in this trial and their families; all the investigators, site personnel, and coordinating investigators; and Rhonda Charles, Ph.D. (Chameleon Communications International with funding from Teva Pharmaceuticals), for editorial assistance with an earlier version of the manuscript.

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